human papilloma virus dna in nongenital seborrheic keratosis

background: seborrheic keratoses (sk) are common, benign and often multiple skin tumors with disputed etiology. a follicular origin, late onset nevoid disturbance or local arrest in maturation of keratinocytes have been proposed. human papilloma virus (hpv) has been detected in a small number of cases, particularly those from the genital region. objectives: the aim of our study was to evaluate the presence of hpv 6/11, 31 and 33 dna in sk of nongenital regions. materials and methods: we examined 49 biopsy specimens of nongenital sk for the presence of hpv dna using pcr technique (inno-lipa hpv genotyping extra). results: the sk specimens (n = 49) were negative for all hpv probes (types 6/11, 31 and 33) tested. genital wart specimens (n = 2) were positive for types 6/11, 31 and 33 hpv dna (positive controls); while chronic dermatitis specimens (n = 10) were negative for all hpv types (negative controls). conclusions: our study results demonstrate that hpv types 6/11, 31 and 33 cannot be causative in sk of nongenital regions.